Jackson Police Sgt. Roderick Holmes said in a news release the wreck happened about 8 p.m. Wednesday on an entry ramp on Interstate-55 during heavy rains.
Holmes says the bus driver, 31-year-old Erika Nixon, is charged with misdemeanor DUI.
First responders said all the passengers were safely removed from the bus. Twenty-two of them were sent to hospitals in the area. No serious injuries have been reported.
It was not immediately known whether Nixon has an attorney.